Pituitary Thyrotropic Cells Are Affected by Steroid Hormones
نویسنده
چکیده
Thyrotrophs are basophilic TSH hormone-producing cells occurring in pars distalis (pd) and pars tuberalis (pt) of the adenohypophysis. These cells are involved in the regulation of thyroid hormones secretion through the hypothalamic-pituitary-thyroid complex. Within the thyrotrope subsets other neuroendocrine peptides are co-localized with TSH hormonesecretogranins/chromogranins, a highly conserved polypeptide termed 7B2, a neuropeptide substance P, neuromedin B, galanin, and calretinin. Based on previously reported data, they may function as local modulators of TSH secretion in an autocrine or a paracrine fashion. However, the precise function of these neuroendocrine peptides in thyrotrophs is yet to be explained.
منابع مشابه
A Comparative study of synthetic carp GnRH and carp pituitary homogenate effects on in vitro steroidogenesis of oocytes in common carp (Cyprinus carpio)
Vitellogenic stage carp ovaries were collected aseptically and the cells of ovarian follicles were dispersed by trypsin treatment and cultivated as monolayer. Control cultures were grown in medium M199 alone. Media for experimental cultures were supplemented either with 100 µl ml-1 of CPH and CPS-carp GnRH (cultivated pituitary cell secretion affected by 10-6, 10-8, 10-10 M carp GnRH). The dire...
متن کاملMono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients.
In a series of 12 patients (eight women and four men, aged between 20 and 62 years), operated on for a pituitary adenoma shown to be thyrotropic by immunocytochemistry, we performed a retrospective and comparative analysis of clinical and biological data, tumor studies including immunocytochemistry with double labeling, and proliferation marker (proliferative cell nuclear antigen (PCNA) and Ki-...
متن کاملPerspectivesin CancerResearch Conditioned Tumorigenicity of Activated Oncogenes1
In his classical review on conditioned and autonomous neo plasms (1) Jacob Furili defined distinct stages in the develop ment and progression of hormone-dependent tumors. His in terest in the endocrine organs and their target tissues was based on the insight that they provided the best available system to analyze the relationship between well defined host factors that regulate the number of cel...
متن کاملPathophysiological mechanisms of gonadotropins– and steroid hormones–related genes in etiology of polycystic ovary syndrome
Objective(s): Polycystic ovary syndrome (PCOS) is an endocrinopathy in women, which, unlike its impact on fertility and health of women, there is no clear understanding about the causal mechanisms of this pathogenesis. The aim of this review paper is to investigate the pathophysiological pathways affecting the PCOS etiology, based on functions of gonadotropins– and steroid hormones–related gene...
متن کاملReactive Splenomegaly and Variation of Lymphoid-plasma Cell Population Associated with a Mouse Pituitary Thyrotropic Tumor.
A transplantable thyrotropic pituitary tumor, subline L24a, which grew after 13 months of dormancy in an intact mouse was associated in its early passage with a variety of lymphoid tumors. On subsequent passage, slow growth over a 6to 12month period was regularly accompanied by striking splenomegaly without lymphoid or thymic neoplasia. The enlargement was due to a great increase in cells of th...
متن کامل